Four factors are involved in the pathogenesis of acne.
~ Increased production of sebum by sebaceous glands
~ Cornification of pilosebaceous ducts
~ An abnormality of microbial flora
~ Products of inflammation produced by Propionibacterium acnes such as lipase, protease, hyaluronidase and chemotactic factors. These products are comedogenic.
The factors that affect acne are genetic factor, androgens, extreme heat and humidity, stress, menstruation, sweating, dust, cosmetics, oil, sugary diet.
How to differentiate acne from other skin rashes on the face?
Acne lesions are polymorphic which comprises of comedones(black heads and white heads), papules, pustules, nodules,cysts and scars. The hallmark of acne is microcomedones. Acne lesions can be present on the chest and back.
Which age group is affected by acne?
Acne begins when the sebaceous glands become active at puberty which peaks at 14-18 years of age. It may reduce in severity thereafter but in some individuals it may continue until middle age.